靶向调控HO-1/NOX2治疗帕金森病的新进展

王玉敏, 王月华, 杜冠华, 王洪权

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (23) : 2024-2027.

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中国药学杂志
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中国药学杂志 ›› 2015, Vol. 50 ›› Issue (23) : 2024-2027. DOI: 10.11669/cpj.2015.23.003
综述

靶向调控HO-1/NOX2治疗帕金森病的新进展

  • 王玉敏1a, 王月华2, 杜冠华2*, 王洪权1b,2*
作者信息 +

Research Progress of Targeting HO-1/NOX2 Pathway for the Treatment of Parkinson's Disease

  • WANG Yu-min1a, WANG Yue-hua2,DU Guan-hua2*,WANG Hong-quan1b,2*
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文章历史 +

摘要

探讨氧化应激参与帕金森病(PD)的发病机制。还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶 (NADPH oxidases,NOX)介导产生的活性氧参与帕金森病病理机制,笔者就还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶在帕金森病中的作用的研究历史进行了梳理,同时对血红素氧化酶-1在帕金森病中的神经保护作用及其与还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶的相互关系进行了综述,提出通过调控HO-1并可经还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶/活性氧通路能够在帕金森病中具有抗损伤作用,因此,筛选调控HO-1/NOX2轴有可能成为帕金森病治疗的新靶点。

Abstract

Accumulating evidence strongly supports the involvement of oxidative stress in the etiology of Parkinson's disease (PD). ROS derived from the NOX2-containing NADPH oxidase play important role in the pathogenesis of PD. Our intent was to review the research history about the role of NOX2-containing NADPH oxidase in PD. Neuroprotective effect of heme oxygenase-1 (HO-1) in protecting neurons against PD-related neurotoxin-induced oxidative stress dependant injury, and a major emphasis has been on the relationship between HO-1 and NOX2-containing NADPH oxidase.Specific activation of HO-1 gene expression by pharmacological modulation may represent a novel target for therapeutic treatment of PD through inhibiting NOX/ROS. A new target for PD therapy through inhibiting NOX/ROS, thereby modulating HO-1/NOX2 axis is highlighted.

关键词

还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶 / 血红素加氧酶-1 / 帕金森病 / 神经保护

Key words

NADPH oxidases / heme oxygenase-1(HO-1) / Parkinson's disease / neuroprotection

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王玉敏, 王月华, 杜冠华, 王洪权. 靶向调控HO-1/NOX2治疗帕金森病的新进展[J]. 中国药学杂志, 2015, 50(23): 2024-2027 https://doi.org/10.11669/cpj.2015.23.003
WANG Yu-min, WANG Yue-hua,DU Guan-hua,WANG Hong-quan. Research Progress of Targeting HO-1/NOX2 Pathway for the Treatment of Parkinson's Disease[J]. Chinese Pharmaceutical Journal, 2015, 50(23): 2024-2027 https://doi.org/10.11669/cpj.2015.23.003
中图分类号： R741.05   

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基金

国家自然科学基金资助项目(81450036; 81260196);内蒙古自治区高等学校青年科技英才支持计划资助项目(NJYT-13-B20); 内蒙古自治区人才开发基金资助项目;内蒙古自然科学基金资助项目(2013MS1176、2014MS0892、2014BS0802、2014MS0814、2015BS0812);内蒙古自治区高等学校科学研究资助项目(NJZZ12306; NJZY234;NJZZ14271);内蒙古教育厅高校创新平台培育资助项目;内蒙古人类遗传病研究重点实验室资助项目;赤峰学院科研创新团队建设计划资助项目
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